It binds GHS-R1a with high affinity but shows minimal activity at other receptor systems, including those mediating cortisol release (CRH/ACTH axis), prolactin release, or appetite stimulation pathways independent of GH signaling
Simultaneously, GLP-1 suppresses glucagon secretion from pancreatic alpha cells, reducing hepatic glucose production
Although adverse reactions to intravenous, intramuscular or subcutaneous injection of 0.9% benzyl alcohol are not known to occur in man, experimental studies of small volume parenteral preparations containing 0.9% benzyl alcohol in several species of animals have indicated that an estimated intravenous dose up to 30 mL may be safely given to an adult without toxic effects
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For repeated measures data, two-way repeated measures ANOVA (2-way RM ANOVA) was employed
The patent, Semi-Recombinant Preparation Of GLP-I Analogues, describes a method for producing GLP-1s