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Oral semaglutide demonstrated a superior reduction in HbA 1c (a measure of blood sugar control) over placebo in the trial and showed a well-tolerated safety profile consistent with previous Novo Nordisk semaglutide trials

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The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients

2.5 Ferroptosis in neurodegenerative pathogenesis Iron is the most abundant transition metal in the human brain and participates in vital CNS functions such as mitochondrial energy transduction, enzymatic catalysis, myelination, synaptic plasticity, and neurotransmitter synthesis and degradation (57)