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In a randomized controlled trial by Xie et al

The Middle East Hyperammonemia and Urea Cycle Disorders Scientific Group include an expert panel of metabolic specialists from countries in the Middle East as well as renowned international advisors

Minimizing Side Effects Our standard approach minimizes side effects through: Gradual dose titration not rushing the escalation schedule is the single most important factor in tolerability Adequate hydration and fiber helps manage GI effects Protein-forward nutrition 0.7 to 1.0 grams per pound of ideal body weight daily, distributed across meals Patient education knowing what to expect and when to call us Side effect mitigation medications when needed Most patients experience some side effects during the first few weeks, and most find them manageable with the approaches above

Journal of Young Pharmacists

Clinical trial data shows that up to 50% of participants experienced some form of abdominal distension during treatment, with symptoms most pronounced during dose escalation and the early weeks

Then, the optional density at 450 nm was measured using a microplate reader (Liuyi, Beijing, China)