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In human splenocyte cultures, IL-2 levels rose significantly within just five hours of exposure [17]

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There is also a study that indicates EGF and IGF1 work in synergy to promote keratinocyte (skin cell) proliferation

Sikiric et al., 2020b) is focused on the particular skin wound therapy, incisional/excisional wound (Seiwerth et al., 1997), deep burns (Mikus et al., 2001), diabetic ulcer (Tkalecevic et al., 2007), alkali burns (Huang et al., 2015), and healing of various other tissue types (Staresinic et al., 2003

[1] But, of course, were here to talk about skincare