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126 In a clinical trial involving cognitively intact individuals aged 4570 years at risk for AD, liraglutide administration for 12 weeks enhanced intrinsic connectivity within the default mode network as measured by resting-state functional magnetic resonance imaging, although no significant cognitive improvements were observed during the study period

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Gastric surgery, such as weight loss procedures, can also lead to vitamin B12 deficiency by reducing the number of cells needed to secrete stomach acid and intrinsic factor

Although glucose-lowering medications may reduce dementia risk through glycemic control, these medications may confer differential benefits to the brain due to activities unique to their different mechanisms of action

Objective data helps determine whether therapy is working and how adjustments should occur

The Keap1/Nrf2/ARE pathway is a key mediator of cytoprotective responses to oxidative and electrophilic stressors