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Expression of GLP-1R V229A was again associated with significantly improved insulin secretion fold-increases to exendin-4, but in this case no changes were detected under 11 mM glucose alone conditions, with the improved fold being a consequence of enhanced insulin secretion versus WT GLP-1R during the exendin-4 stimulation period (Figure 8H, I)

Neuron-released oligomeric -synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

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Holubov M, Hrub L, Popelov A, Bencze M, Praienkov V, Gengler S, et al

Furthermore, safety data is inadequate