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In diet-induced obesity (DIO) mouse models, 5-Amino-1MQ administered intraperitoneally produced a 7% reduction in body weight over 11 days compared to vehicle-treated controls, despite no change in food intake

At 72 weeks, tirzepatide produced a mean weight reduction of 20.2% compared to 13.7% for semaglutide

Because the study is exploratory for epigenetic outcomes, we did not adjust p -values for multiple comparisons across the different clocks

Understanding the Long-Term Safety Profile of Tirzepatide in 2026 As we enter 2026, the clinical landscape for weight management has shifted dramatically

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