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2012;7(7):e42357

Freezing causes ice crystal formation that physically disrupts peptide chains

Microbial osteoporosis: the interplay between the gut microbiota and bones via host metabolism and immunity

PMCID: PMC6770193.

As oxidative stress increases, further stimulation of pro-inflammatory cytokines such as TNF- and IL-1 increases and contributes to synaptic dysfunction and neuronal degeneration ( These studies suggest that the loss of antioxidant defense is an early biochemical event rather than a late-stage consequence of neuronal death