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Dose escalation periods: When increasing from 0.25 mg to 0.5 mg (typically after 4 weeks), and subsequently to 1 mg or 2 mg if required, patients may experience a temporary resurgence of digestive symptoms

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Professional societies: Recommend discontinuation at least 2 months prior to conception

Some people use them together, others use one or the other

Desiree Granados Quick Summary: Semaglutide can be associated with fatigue in some individuals, potentially related to gastrointestinal side effects, changes in appetite and blood sugar regulation, or adjustments in energy metabolism