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3.67 times higher risk of gastroparesis, or stomach paralysis, which limits the passage of food from the stomach to the small intestine and results in symptoms like vomiting, nausea and abdominal pain

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Some early reports suggest that reducing dose frequency may help certain patients maintain weight loss, but experts also caution that microdosing itself is loosely defined and not supported by robust long-term data

The Phase 2 protocol used a one-week washout after the final tirzepatide dose before retatrutide initiation at 2 mg