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In our study, we opted for larger voxels (24-27 mL) to improve the accuracy of quantifying low-concentration metabolites (i.e

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Definition of hyperprogression Hyperprogression was defined using the previously established criteria for solid tumors as progressive disease in the first 8 weeks after treatment initiation, a 10 mm minimum increase in the measurable lesions, plus: (i) an increase of 40% in the sum of target lesions compared with baseline and/or (ii) an increase of 20% in the sum of the target lesions compared with baseline plus the appearance of new lesions in at least two different organs

The results of the phase III trial indicate common side effects in all groups [88]