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Urgent medical attention required: Patients should seek immediate medical help (call 999 or attend A&E) if they experience actual loss of consciousness (syncope), chest pain, severe breathlessness, slurred speech, facial drooping, weakness on one side of the body, or severe headache

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The participant identification number was included as a random effect to account for within-subject variability

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Yes Side effects during the first 4 weeks are expected and usually improve