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Compared to natural ligands, retatrutide shows lower potency at GLP-1 and glucagon receptors but higher potency at GIP receptors

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With newer GLP-1based therapies now emerging, the field has an opportunity to test whether different drugs in this class have distinct effects on aging biology and to identify which patients may benefit most. Larger clinical trials will be needed to confirm these findings, determine how long the effects persist, and establish optimal dosing strategies and treatment durations for both people with HIV and the broader population

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