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Even with this unprecedented incretin power, the extratumoral microenvironment, hyperinsulinemia-driven FAK/PYK2 activation and collagen remodeling in adipose, kidney, liver, and heart, remains untouched and continues to fuel residual progression in 5070 % of obesity, T2D, CKD & HFpEF patients

10.1017/S0007114508162985 6

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Control del peso a largo plazo Para lograr y mantener un peso saludable a largo plazo, se necesitan cambios que sean sostenibles

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NICE guidance emphasises that pharmacological interventions should be part of a multicomponent approach that includes dietary modification, increased physical activity, and behavioural strategies for optimal and sustainable outcomes