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Thus, we followed patients from cohort entry until the outcome (detailed below), switching or discontinuation of study drug (defined as the lack of a prescription by the end of the 90 day grace period), death from any cause other than suicide, end of registration with the CPRD, or end of the study period (29 March 2021), whichever occurred first

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As glucocorticoid concentrations in the blood rise, the hypothalamus and pituitary gland reduce their signaling to the adrenal glands to prevent additional glucocorticoid secretion (Figure 4

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People should be aware that there are gastrointestinal symptoms, such as nausea, vomiting, diarrhea and abdominal pain irritation/inflammation at the injection site