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For whom should GLP-1 agonists be considered

Diagnostic evaluation may include: Detailed neurological examination assessing sensation, reflexes, and motor function Hemoglobin A1c measurement to evaluate recent glycemic control Vitamin B12 levels and methylmalonic acid (if B12 is borderline) Serum protein electrophoresis (SPEP) and immunofixation to screen for paraproteinemia Thyroid function tests, as hypothyroidism can contribute to neuropathic symptoms Comprehensive metabolic panel to assess renal and hepatic function Nerve conduction studies in selected cases with atypical features Management strategies focus on optimizing glycemic control, which remains the most evidence-based intervention for preventing and potentially improving diabetic neuropathy

Now that the TGA has issued this warning, pharmacists should mention it every first dispensing of these medicines, she said

Tirzepatide did not demonstrate detectable attenuation of weight reduction-induced decreases in sleeping or 24-h energy expenditure, but there was a reduction in respiratory exchange ratio in the tirzepatide treatment arm compared with that in the placebo arm, consistent with an increase in fat oxidation

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Yes restoring SCFA production, mucosal integrity, and microbial diversity helps maintain natural GLP-1 signaling without medication