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McRobie DJ et al

Fortunately for most GLP-1 users, the gastrointestinal side effects are mild to moderate in severity, generally tolerable and tend to improve with time, especially with careful and slow dose titration

Both have mild and similar side effect profiles because they activate the same growth hormone pathway

Mark Hyman, MD (Archetype), Functional Medicine Expert

Note: Tirzepatide is the only one of these medications that is both a GLP-1 and GIP agonist

How Tirzepatide Works and Cost Considerations Tirzepatide, found in both Mounjaro and Zepbound, targets hormone receptors including GLP-1 and GIP, which impacts insulin regulation and appetite