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PLoS One 2013
Most of the research on these compounds remains preclinical, and the committee vote did not add a single study to it
Most patients start at 0.25 mg/wk and gradually increase to 0.5, 1, 1.75, or 2.5 mg/wk
Thus, until the relationships between total protein intake and muscle intake and the creatinine index are well defined for ESRD patients, some caution must be exercised in interpreting the creatinine index, particularly if the diet of the individual in question is particularly high or low in these nutrients.
Its a lower, more sustainable dose that still gets results
Its labelling carries the FDA disclaimer that the product has not been found safe and effective
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