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They are usually safe but can cause problems for some people

Product quality risks: unregulated peptides may contain impurities, endotoxins, or incorrect quantities of active compound

NCT04184622 ), and in SURPASS-2 it outperformed semaglutide on glucose and weight endpoints in type 2 diabetes ( Fras et al., NEJM 2021 )

doi: 10.1517/14712598.2012.634793

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This multi-receptor mechanism distinguishes retatrutide from earlier generations of incretin-based research compounds including GLP-1 mono-agonists such as semaglutide, and dual GIP/GLP-1 agonists such as tirzepatide by introducing glucagon receptor activation as an additional metabolic axis