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It was first characterized by Professor Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s

Some symptoms of vitamin B12 deficiency include: Weakness and tiredness Pale or yellowish skin Loss of appetite Heart palpitations Mouth or tongue soreness Tingling or "pins and needles" sensation in your hands and feet Shortness of breath Dizziness Blurry vision Mood swings or personality changes You are more at-risk for developing vitamin B12 deficiency if you are: Pregnant Over 65 Vegan Take medicine for diabetes Take medicine for heartburn Have had surgery to remove part of your bowels Medically Reviewed on 6/23/2026 Mayo Clinic: "Vitamin B-12." National Institutes of Health: "Vitamin B12." Oregon State University: "Vitamin B12." Top What Happens if You Take Too Much Vitamin B12 Related Articles 22 Healthy Foods High in B VitaminsAny deficiency of B vitamins can lead to various health conditions

They indicate that the innate repair receptor system plays a role across multiple types of tissue injury and inflammation

The effectiveness duration of vitamin B12 depends on multiple elements, as per your inquiries about its operational period

the product is sterile, non-pyrogenic, with pH 4.57.0 per manufacturing specification

That is the reason why it is safe to use that within that period and not beyond that