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Using the treatment-regimen estimandwhich incorporates treatment discontinuation and certain additional eventsaverage weight loss was: 12.2% with survodutide 3.6 mg 13.0% with survodutide 6 mg 5.4% with placebo A separate efficacy estimand, designed to estimate results had participants remained on treatment without prohibited weight-management therapy, produced weight loss of up to 16.6%

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