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12 , e1001780 (2015)

Because chelation can also affect essential minerals, it is typically done under medical supervision and supported with nutritional strategies to maintain mineral balance and overall detoxification

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Rather than binding directly to the enzyme active site, copper ions interfere with the enzymes function at concentrations achievable through topical or injectable application

However, it is important to note that berberine is not a cure for any medical condition and evidence for many uses is still emerging

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