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Rushing through titration increases the likelihood of discontinuing treatment due to intolerable symptoms
Do not take more than one medicine that has acetaminophen without talking with a member of your care team
The Phase 2 trial (Jastreboff et al., NEJM, 2023) used the same route
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Importantly, a prespecified exploratory analysis of the AMPLITUDE-O trial found comparable benefits of GLP-1 RA treatment in participants who were receiving an SGLT2i as background therapy (15% of the total trial population) and those who were not [241]
Experts anticipate a shift towards combination therapies that utilize multiple medications to address various hormones related to body regulation, potentially leading to improved outcomes for obesity management
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