This weight loss is typically sustainable and can lead to improvements in overall metabolic health

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u003ca href=u0022#Do-GLP-1-Patches-Actually-Work?u0022u003eNo studies show that these patches actually worku003c/au003e for promoting weight loss or improving metabolic health
Where there are differences of detail these are explained in the Handbook to the Constitution
Haws et al ., 2020 "Effect of setmelanotide, a melanocortin-4 receptor agonist, on obesity in Bardet-Biedl syndrome"
They are fast-acting and effective, but long-term use causes skin thinning, telangiectasia (visible blood vessels), and tachyphylaxis (reduced effectiveness over time)