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Exposure to ionizing radiation is well known to promote oxygen radical formation within biological systems through radiolysis (interaction of radiation and water).12 Hypoxia or/and hyperoxia condition in cells has been noted to generate numerous oxygen-derived radicals.13 Besides, a couple of therapeutic drugs such as acetaminophen have been reported to cause oxidizing effects on cells, consequently leading to formation of oxygen radicals through the activity of drug metabolizing enzymes known as cytochrome P -450 system.14 5

To identify the downstream targets of ceramide in nucleated cells, a ceramide signaling network was generated by mining the PubMed literature database

Shaking to dissolve faster Foam = denaturation

Hargrove ME, Wang J, Ting CC

The published evidence does not support that level of specificity

A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides