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A Cochrane systematic review of NAC for COPD exacerbations (39 RCTs, n=7,436) found that NAC and other mucolytics significantly reduced the frequency of acute exacerbations (OR 0.75, 95% CI 0.62-0.92) (Poole et al., Cochrane Database Syst Rev, 2019) [43]

This research was funded by National Natural Science Foundation of China, grant number 82560147, Health Commission Science and Technology Fund Project of Guizhou Province, grant number gzwkj2025279 and Xiangshan Talent Project of Zhuhai Peoples Hospital, grant number 2023XSYC-02