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[97] observed a potential association between semaglutide and NAION, with incidence rates of 4.28 and 7.64 per 1,000 person-years in patients with T2DM and those who were overweight or obese, respectively, over 36 months

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Ipamorelin studies in rats have observed that the peptide may prevent bone loss following prolonged glucocorticoid exposure, and also may induce up to a four-fold increase in bone formation