The mechanism underlying these gastrointestinal cytoprotection-associated findings has been attributed in published research to NO-related maintenance of mucosal microvascular function and preservation of endothelial integrity, rather than to simple acid suppression
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MLT was found to inhibit ferroptosis in subarachnoid haemorrhage-mediated neuronal injury by activating genes such as Nrf2 and Heme oxygenase-1 (HO-1) (Ma et al., 2023)
IL-17 deficiency aggravates the streptozotocin-induced diabetic nephropathy through the reduction of autophagosome formation in mice
Journal of Aging Research, 2012, 17
Superoxide reacts with NO to form peroxynitrite (ONOO ), a toxic compound that depletes NO and worsens endothelial dysfunction (Li H