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Glucose-1-phosphate is an allosteric activator of G6PDH resulting in an enhanced level of NADPH production in response to oxidative stress

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These studies indicate that overproduction of glutathione drives the survival and growth of a small subset of lymphoid tumor cells in 3D gels and xenografts, likely TIC or TIC-like cells, and that glutathione is selectively required for tumor growth in females of a mouse model of lymphoma