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Studies with NR supplementation in PD or HF patients have provided indications of impacting mitochondrial function in peripheral tissues, although evidence for impacting mitochondria in the primary target tissues was not reported 318,319

Wegovy (semaglutide) and lisdexamfetamine (brand name Elvanse in the UK) are prescription medications used for distinctly different clinical purposes, though both may influence appetite and weight

Semaglutide 2.4 mg (Wegovy) typically produces ~15% weight reduction, liraglutide 3.0 mg (Saxenda) ~8%, and tirzepatide (Zepbound) ~15-21%

Maintenance dosing sustains that activation without further escalation

doi: 10.1002/jcph.443

Thomas MK, Nikooienejad A, Bray R et al (2021) Dual GIP and GLP-1 receptor agonist tirzepatide improves beta-cell function and insulin sensitivity in type 2 diabetes