Emerging research employed lentivirus-mediated shRNA to knock down GLP-1R expression in vitro, resulting in diminished effects of GLP-1RAs on mitochondrial function by day 21, along with impaired mitochondrial autophagy and autophagic clearance
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Mechanistic evidence has indicated that GLP-1RAs promote bone marrow-derived macrophage polarization into the M2 phenotype via the cAMP-PKA-signal transducers and activators of the transcription 3 (STAT3) pathway [137, 138]
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Frontiers in Endocrinology , 14 , 10230051