SURMOUNT-OSA showed about a 27 events-per-hour AHI reduction in the treatment arm, which Express Scripts reviewers cite when applying the OSA criteria
Specifically, carriers of GIPR variants that are pharmacologically classified as loss-of-function variants with reduced cell surface expression, cAMP production, beta arrestin 2 recruitment, internalization, and endosomal signaling have consistently been associated with lower adiposity-related traits, including BMI (103) and nominally lower prevalence of obesity (39, 9799)
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