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For semaglutide, discontinuation at least 2 months before a planned pregnancy is recommended due to its long half-life
79 While the direct renoprotective mechanisms of GLP-1RAs are still under investigation, their ability to enhance natriuresis and suppress pathogenic angiotensin II production presents a valuable therapeutic strategy in HFpEF complicated by CKD
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Freitas S, Merkle HP, Gander B
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Patients receiving the maximum recommended dose of Mounjaro (15 mg) as monotherapy had an average 1.6% reduction in hemoglobin A1c (HbA1c, a measure of blood sugar control) compared to placebo
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