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L-Carnitine is a naturally produced compound derived from the amino acids lysine and methionine

Therefore, NRF2 plays an important role in maintaining the cell redox balance and preventing ferroptosis

Tissue sections were then incubated in 6% BSA and 2% horse serum in PBS-0.1% Triton X-100 for 1 h at RT to block nonspecific binding

There are two pathways of remethylation and one pathway of transsulfuration

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Also, the adverse cardiovascular safety in clinical trials before 2008 was evaluated based on populations that were not necessarily at high risk of cardiovascular disease and the follow-up duration was relatively short (usually less than 12 months)