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Discuss key efficacy and tolerability data from clinical trials published to date with oral semaglutide
It states that semaglutide does not directly harm thyroid tissue or worsen hypothyroidism itself, and that recent data shows GLP-1 receptor agonists do not directly damage the thyroid
In rodents, GLP-1 receptors are expressed on thyroid C-cells, and chronic stimulation may promote cellular proliferation
Lowers Oxidative Stress: As a powerful antioxidant, glutathione protects the cells from oxidative stress
Injecting a nonsterile medication could result in serious complications like infections and sepsis
Overall, our findings can contribute to guidance for rational GLP-1RA usage in Asia,suggesting that GLP-1 analogues are desirable for T2D patients with normal BMI as well as for those with overweight/obesity
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