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Hair loss is usually due to rapid weight loss or low nutrition, though some reports suggest a possible link between GLP-1s and alopecia

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2.4 Immunomodulatory and anti-inflammatory effects GLP-1 receptor agonists have substantial immunomodulatory effects that beyond basic metabolic control

Engeletin, a flavonoid from Smilax glabra , suppressed Toll-like receptor 4-NF-B signaling, reduced the expression of IL-1, IL-6, and TNF-, and inhibited macrophage polarization from the pro-inflammatory M1 phenotype

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Participants were randomized to receive a placebo (dummy medication) or retatrutide in doses of 4, 9, or 12 milligrams (mg)