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Concerning signs of overdose include: Marked unresponsiveness or extreme difficulty waking the person Very slow, shallow, or irregular breathing Slow heart rate or dangerously low blood pressure Repeated vomiting while unresponsive Seizures or severe agitation What to Do If You Suspect a GHB Overdose: If you suspect someone is experiencing a GHB overdose, immediate action can save their life: Call 911 immediately Clearly describe suspected GHB, GBL, or 1,4-BD exposure Check responsiveness and breathing If breathing is inadequate, begin rescue breathing or CPR if youre trained Use the recovery position Place an unconscious but breathing person on their side to reduce aspiration risk Do not give anything by mouth Never give water, food, or other substances to an unresponsive person Do not induce vomiting This increases aspiration risk Gather evidence Collect any containers, product labels, or witness information for medical responders Report all substances Tell emergency personnel about any alcohol, prescription medications, or other drugs that may have been used Important note: Naloxone (Narcan) is not effective for reversing GHB overdose, though it may be administered if opioid co-ingestion is suspected while awaiting emergency help