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This rigorous evaluation has led to the accelerated recognition of the cardioprotective, renoprotective, and vasoprotective effects of SGLT2i ( Figure 1 )

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Additionally, the weight loss was superior compared with what adults achieved with semaglutide 2.4 mg alone (Wegovy, Novo Nordisk) or cagrilintide 2.4 mg alone (Novo Nordisk)

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Endothelin receptor antagonists (ERAs) have been studied in diabetes and CKD for over a decade, with early studies ending prematurely because of complications associated with fluid retention