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As such, TGR5 activation stimulates secretion of GLP-1, while FXR activation reduces GLP-1 secretion, demonstrating a complex interplay between the differential bile acid pool composition and gutbrain signaling 270,271

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Biol Psychiatry 73(9):915923 Hsu TM et al (2015) Hippocampal GLP-1 receptors influence food intake, meal size, and effort-based responding for food through volume transmission

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Liraglutide weight loss data (SCALE trials) The SCALE (Satiety and Clinical Adiposity, Liraglutide Evidence) trial program established liraglutide 3.0mg as a weight loss medication

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USA 109 , 1343413439 (2012)

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