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10.3390/mi15020186 9 ChangY.WangX.AnZ.WangH

This review has highlighted how mitochondrial-immune crosstalk is a unifying paradigm explaining much of perioperative organ dysfunction, from sterile inflammation in the heart and brain to delayed healing and infection susceptibility

These phytochemicals can interact with different types of receptors in the central nervous system (CNS), such as N-methyl-D-aspartate receptor (NMDAR), Gamma-aminobutyric acid receptor (GABAAR), and -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), channels like voltage gated sodium, potassium, and calcium channels, and other enzymes and pathways that play a significant role in the initiation and propagation of epileptic seizures

This is the same mechanism targeted by topical brightening agents, delivered systemically instead, and the effect is best understood as a gradual, cumulative brightening support across a series rather than an overnight change

That means more benefits with fewer side effects like the increased appetite from the release of the stress hormone cortisol, which other peptides can cause