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The IGF-1/IGF-1R system has been shown to be an important promoter of tumor growth in various cancers, promoting tumor progression and metastasis by regulating multiple signaling pathways, such as those of PI3K/AKT and MAPK/ERK signaling (78,94)
For instance, Vivanis NanoPortal technology utilizes nanostructured titanium oxide membranes with vertically aligned nanotubes to enable sustained, tunable drug delivery through pore-size-dependent diffusion kinetics [47]
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