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This review paper highlights the influence of cellular energy metabolism on fat burning, emphasizing therapies that target cellular energy dynamics as promising targets for obesity

Additional information Peer review information Nature Metabolism thanks Dominique Langin and the other, anonymous reviewers for their contribution to the peer review of this work

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The Mechanism AOD-9604s proposed mechanism of action: Direct stimulation of lipolysis in adipocytes, mimicking the lipolytic effect of full hGH Inhibition of lipogenesis reducing new fat deposition Minimal effect on circulating IGF-1 unlike full hGH Minimal insulin resistance effects a feature that distinguishes AOD-9604 from full hGH administration No significant effect on growth hormone release operates as a standalone fat loss mechanism Clinical Development History AOD-9604 has an unusual development history

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