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If you havent had a regular source of B12 for more than a few months, take 2,000 g once a day for 2 weeks to replenish your stores
Cases of allergic reactions to hydroxocobalamin with tolerance to cyanocobalamin were documented in several instances (1, 2, 3)
The answer is yes
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High-dose therapy may also cause a brief increase in blood pressure, though this usually returns to baseline within a few hours
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