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By increasing the sodium load at the distal renal tubule, hydrochlorothiazide indirectly increases potassium excretion via the sodium-potassium exchange mechanism

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Thus, structures of glutathionylated glutaredoxins 31,43,44,45 most likely resemble enzyme species F, whereas similar structures of complexes between reduced glutaredoxin and GSH with longer sulfursulfur distances 24,46 do not represent the interaction with GSH (but probably also resemble species F)