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Failure of DNA repair induces apoptosis through p53 activation, mitochondrial pathway induction, and persistent DNA damage response (DDR) signaling 8-10

Enzymatic and non-enzymatic reactions are both necessary for ROS and RNS production

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Therefore, the pyruvatecysteineglutathione system/glycineROS metabolic pathway physiologically contributes to antibiotic resistance that can be reversed by exogenous pyruvate in vitro and in vivo