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Genetic variants in the AOC1 gene (encoding the DAO enzyme) and the HNMT gene are the primary genetic factors
Current guidelines from the American Society for Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity (IFSO) support consideration in patients with BMI 35 kg/m regardless of comorbidities, or BMI 30-34.9 kg/m with metabolic disease
You want to treat obstructive sleep apnea (OSA)
Its anti-inflammatory properties make it effective in treating conditions like acne, rosacea, and eczema
Some protocols run 50100 mcg but the risk/benefit ratio shifts considerably above 50 mcg without meaningful additional evidence of proportional benefit
doi: 10.1016/j.bpc.2015.03.009 405 GermainABarupalDKLevineSMHansonMR
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