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How We Got Here: Origins and Naming Both molecules trace back to melanocortin research aimed at a tan without UV as a way to reduce skin-cancer risk from sun exposure

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Subsequently, the IL-10 receptor/STAT3 signaling pathway in microglia is autocrinally activated, thereby promoting the expression and release of -endorphin, the latter acts on -opioid receptors on neurons to produce analgesic and neuroprotective effects (103105)

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