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GHK-Cu is a photolabile copper(II) complex, and freeze-thaw cycling can disrupt the copper coordination sphere independently of any damage to the peptide backbone

Active repletion through supplementation or injections is needed

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Observations from PIONEER REAL Netherlands add to those previously reported in the SURE Netherlands study and highlight that both formulations of semaglutide (oral and subcutaneous) can provide clinical improvements in the key management goals (glycaemic control and weight loss) for individuals living with T2D [30]

What is unusual about the new study, and what it adds to the discussion, is that it found a disproportionality signal specifically among people who were taking both semaglutide medications and antidepressants and benzodiazepines