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Following the prescribed titration schedule (starting low and increasing gradually) minimizes these effects and, by extension, minimizes the dehydration that drives UTI risk
Coverage often limits to patients with a BMI of 30 or higher (or 27+ with weight-related comorbidities)
Pramlintide has a short half-life (approximately 50 minutes), requiring multiple daily administrations alongside meals
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Scheck, S
As GEP44 acts directly on muscle tissue, while its effects on islets require concomitant Y1-R antagonism, activation of Y1-R expressed in muscle tissue may ultimately prove to be a critical factor in reducing serum glucose levels, alongside any potential effects on insulin secretion and glucagon release
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