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Responses to GLP-1 agonists differ greatly between individuals

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Activated T cells and macrophages in the synovium form an environment conducive to ferroptosis and inflammation, and also induce ROS production in a positive feedback manner, thus promoting the release of pro-inflammatory factors into the synovium and synovial fluid and further amplifying synovial inflammation (84)

Therefore, the beyond-use date (BUD) provided by the pharmacy is critical

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